Skin tissue perfusion mapping triggered by an audio-(de)modulated reference signal

Spatial mapping of skin perfusion provides essential information about physiological processes that are often hidden from the eyes of the examining physician. The perfusion map quality depends on several key factors, such as the camera system type, frame rate, sensitivity, or signal-to-noise ratio. When investigating physiological parameters, the reference signal allows for increasing the spatial resolution of the photoplethysmography imaging (PPGI) system. On the other hand, it increases the system complexity and the synchronization prerequisites. Our solution is a hardware device that modulates the reference biosignal into the audio frequency band. This signal is connected to the mic input of a digital camera or a smartphone, enabling the transformation of such a device into a PPGI measurement system even in the case of compressed video recording using lock-in amplification technique. It also brings the possibility of synchronous recording of PPGI and another reference signal such as conventional photoplethysmogram or electrocardiogram.