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Updated: Aug 31, 2025

Microgel-Extracellular Matrix Composite Support for the Embedded 3D Printing of Human Neural Constructs
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Nanomaterial integrated 3D printing for biomedical applications.

Liwen Zhang1, Helen Forgham1, Ao Shen1,2

  • 1Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia. r.qiao@uq.edu.au.

Journal of Materials Chemistry. B
|August 22, 2022
PubMed
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3D printing, or additive manufacturing, enables customized biomaterials by integrating nanomaterials into polymers. This review explores novel hybrid materials for tissue engineering and regenerative medicine.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • 3D printing (additive manufacturing) is a key technology for creating customized biomaterials.
  • Biomaterials like metals, ceramics, polymers, and composites are used in 3D printing.
  • Nanomaterials are increasingly combined with polymers to create advanced hybrid materials for biomedical uses.

Purpose of the Study:

  • To review recent advancements in hybrid biomaterials.
  • Focus on nanomaterials integrated with 3D printing for biomedical applications.
  • Summarize mechanisms, properties, and applications of these novel materials.

Main Methods:

  • Literature review of nanomaterial integration in 3D printing.
  • Analysis of various nanomaterials: metal-based, metal-organic frameworks, upconversion, and lipid-based nanoparticles.

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  • Examination of functional properties, advantages, and disadvantages.

    • Main Results:

    • Novel hybrid biomaterials leverage nanomaterials for enhanced functionality in 3D printing.
    • Specific nanomaterials offer unique properties for diverse biomedical applications.
    • The review details mechanisms, properties, and applications of these advanced materials.

    Conclusions:

    • Nanomaterial-enhanced 3D printing offers significant potential for biomedical applications.
    • Challenges remain in the development and implementation of these hybrid materials.
    • Further research is needed to overcome limitations and advance the field.