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Updated: Aug 31, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Heterocycle-containing Noyori-Ikariya catalysts for asymmetric transfer hydrogenation of ketones
Noha Khamis1,2, Guy J Clarkson1, Martin Wills1
1Department of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK. m.wills@warwick.ac.uk.
Abstract:
The synthesis of a range of N-(heterocyclesulfonyl)-functionalised Noyori-Ikariya catalysts is described. The complexes were prepared through a short sequence from C2-symmetric 1,2-diphenylethylene-1,2-diamine (DPEN) and were characterised by a range of methods including X-ray crystallography. The complexes were active catalysts for the asymmetric transfer hydrogenation (ATH) of a range of acetophenone derivatives, giving products of high ee in most cases, with notably good results for ortho-substituted acetophenones.
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