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Neurogenesis and Regeneration of Nervous Tissue

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Related Experiment Video

Updated: Aug 31, 2025

Author Spotlight: Innovative Use of nsPEF to Boost Peripheral Nerve Regeneration

Author Spotlight: Innovative Use of nsPEF to Boost Peripheral Nerve Regeneration

Published on: May 3, 2024

Electroceuticals for peripheral nerve regeneration.

Woo-Youl Maeng¹, Wan-Ling Tseng^2,3, Song Li⁴

¹School of Biomedical Engineering, Korea University, Seoul 02841, Republic of Korea.

|August 22, 2022

Summary

This summary is machine-generated.

This review explores advanced bioelectronic conduits for peripheral nerve regeneration, detailing fabrication methods and device integration for effective electroceutical delivery to enhance neural repair.

Keywords:

conductive conduit electrical stimulation electroceuticals nerve conduit peripheral nerve regeneration

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Last Updated: Aug 31, 2025

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The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

Published on: January 13, 2022

Area of Science:

Biomaterials Science
Neural Engineering
Regenerative Medicine

Background:

Peripheral nerve injury poses significant challenges to restoring function.
Electroceuticals offer a promising avenue for modulating nerve repair mechanisms.
Current bioelectronic devices face hurdles in effective and controllable electroceutical delivery.

Purpose of the Study:

To review modern fabrication methods for bioelectronic conduits for nerve gap bridging.
To discuss the integration of implantable bioelectronic devices for versatile electrical stimulation.
To present evidence of beneficial mechanisms for neural regeneration.

Main Methods:

Summarizing fabrication techniques for conductive biomaterials and manufacturing processes.
Reviewing the integration of wireless energy harvesters, actuators, and sensors in bioelectronic devices.
Compiling in vitro, in vivo, and clinical evidence on electroceutical mechanisms.

Main Results:

Modern fabrication methods enable the creation of bioelectronic conduits for nerve regeneration.
Integrated bioelectronic platforms facilitate versatile electrical stimulation delivery.
Evidence supports the beneficial mechanisms of electroceuticals in neural repair.

Conclusions:

Advanced biofabrication, integrating conductive biomaterials and 3D engineering, is key for neural tissue engineering.
Bioelectronic platforms enhance the delivery of electroceuticals for comprehensive biomimetic therapies.
This approach heralds a new era in peripheral nerve regeneration and neural tissue engineering.