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Bioinspired zwitterionic microgel-based coating: Controllable microstructure, high stability, and anticoagulant

Mengmeng Yao1, Xia Sun2, Zhicheng Guo1

  • 1School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China.

Acta Biomaterialia
|August 22, 2022
PubMed
Summary

A new zwitterionic microgel coating strategy effectively prevents thrombosis and protein adhesion on biomedical devices. This biomimetic approach offers improved stability and controllable surface coverage without anticoagulants.

Keywords:
AntithromboticBionic microstructureMicrogelsNon-foulingZwitterions

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Area of Science:

  • Biomaterials Science
  • Surface Engineering
  • Nanotechnology

Background:

  • Zwitterionic polymers show potential for non-fouling and antithrombotic applications.
  • Controlled surface coverage of zwitterionic polymers remains a challenge for biomedical devices.
  • Thrombosis is a critical failure cause for medical device implantation.

Purpose of the Study:

  • To develop a facile zwitterionic microgel-based coating strategy with controlled surface coverage.
  • To create coatings with enhanced anti-protein adhesive and antithrombotic properties.
  • To provide a versatile coating method for biomedical device applications.

Main Methods:

  • Co-deposition of poly(sulfobetaine methacrylate-co-2-aminoethyl methacrylate) microgel (SAM), polydopamine (PDA), and sulfobetaine-modified polyethyleneimine (PES).
  • Utilized PDA and PES (PDAS) as an intermediate layer for controllable SAM morphology.
  • Investigated coating stability and antithrombotic efficacy via ex vivo blood circulation tests.

Main Results:

  • Achieved controllable morphology of zwitterionic microgel coatings via the PDAS intermediate layer.
  • Demonstrated high anti-protein adhesive properties and inhibition of cell, bacteria, and platelet adhesion.
  • Confirmed improved coating stability and significant reduction in thrombosis without anticoagulants.

Conclusions:

  • The developed SAM/PDAS coating strategy offers high deposition density and controllable morphology.
  • This biomimetic approach provides excellent antifouling and antithrombotic properties.
  • The coating method shows promise for various biomedical device applications, addressing thrombosis concerns.