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Related Experiment Video

Updated: Aug 31, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Propylthiouracil-Induced Skin Vasculitis.

Mariana S Almeida¹, Carina Ramalho¹, Francisco Gomes¹

¹Internal Medicine Department, Centro Hospitalar Barreiro Montijo, Barreiro, PRT.

|August 24, 2022

Summary

This summary is machine-generated.

Propylthiouracil (PTU) can trigger antineutrophil cytoplasmic antibodies (ANCAs), leading to ANCA-associated vasculitis. Discontinuing PTU in a patient with vasculitis symptoms resulted in clinical and analytical improvements.

Keywords:

adverse reactions anca antibodies propylthiouracil purpuric plaques vasculitis

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Granulocyte-dependent Autoantibody-induced Skin Blistering

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Published on: October 12, 2012

Area of Science:

Internal Medicine
Rheumatology
Dermatology

Background:

Propylthiouracil (PTU) is a medication used to treat hyperthyroidism.
PTU use is linked to the development of autoantibodies, including antineutrophil cytoplasmic antibodies (ANCAs).
ANCAs are implicated in the pathogenesis of ANCA-associated systemic vasculitis, particularly the myeloperoxidase subtype (ANCA-MPO).

Observation:

A 61-year-old woman on PTU for one year presented with a three-month history of painless, non-blanching purple patches on her chest and legs.
The lesions were non-pruritic and involved small to medium-sized vessels.
Autoimmunity testing revealed ANCA antibody positivity.

Findings:

A cutaneous biopsy confirmed leukocytoclastic vasculitis/necrotizing vasculitis.
The patient experienced clinical improvement after discontinuing PTU.
Analytical changes associated with vasculitis resolved following drug cessation.

Implications:

This case highlights a potential adverse effect of PTU, specifically drug-induced ANCA-associated vasculitis.
Discontinuation of PTU can lead to remission of ANCA-associated vasculitis.
Clinicians should consider PTU as a potential cause in patients presenting with ANCA positivity and vasculitic symptoms.