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Related Concept Videos

Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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Urinary Bladder01:23

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The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
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Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
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Related Experiment Video

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Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
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Magnetic soft robotic bladder for assisted urination.

Youzhou Yang1,2, Jiaxin Wang1,3, Liu Wang4

  • 1Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China.

Science Advances
|August 24, 2022
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Summary
This summary is machine-generated.

A novel magnetic soft robotic bladder (MRB) offers a new solution for underactive bladders (UABs). This implantable device assists urination by applying mechanical compression, improving bladder pressure and flow.

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Area of Science:

  • Biomedical Engineering
  • Urology
  • Robotics

Background:

  • Underactive bladder (UAB) is characterized by poor detrusor muscle contractility, leading to incomplete and difficult urination.
  • Current treatments like neurostimulation and regenerative medicine for UABs have limited efficacy and potential side effects.

Purpose of the Study:

  • To develop and evaluate an implantable magnetic soft robotic bladder (MRB) to assist urination in UAB patients.
  • To demonstrate the feasibility of MRB-assisted bladder compression and urination.

Main Methods:

  • Fabrication of a biocompatible elastomer composite MRB with optimized magnetic domains.
  • Implantation of the MRB in a porcine model with induced UAB.
  • Assessment of MRB function using in situ computed tomography imaging and urodynamic tests post-implantation.

Main Results:

  • Successful implantation and 14-day functional assessment of the MRB in a porcine model.
  • MRB actuation via external magnetic fields induced effective bladder contraction.
  • Urodynamic tests demonstrated successful urination events with significantly increased bladder pressure and urine flow rate.

Conclusions:

  • The developed MRB provides a promising on-demand mechanical compression method to assist urination in UAB.
  • This robotic approach offers a potential new therapeutic strategy for managing underactive bladder conditions.
  • Further development of MRB technology could lead to improved treatment options for human patients with UABs.