Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adhesion01:14

Adhesion

40.8K
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow...
40.8K
Tagging and Fusion Proteins01:24

Tagging and Fusion Proteins

6.8K
Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...
6.8K
Cell Adhesion in Plants01:14

Cell Adhesion in Plants

2.8K
Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bio-inspired approaches to <i>in vivo</i> DNA data storage systems.

Materials horizons·2026
Same author

Bio-Inspired and Protein-Based Elastomeric Materials.

Polymer science & technology (Washington, D.C.)·2026
Same author

A Substitution-Desymmetrization of Recyclable Poly(β-Thioesters) Strategy for Crystallinity Regulation and High-Performance Adhesives.

Biomacromolecules·2026
Same author

Engineered Protein Nanoparticles Enable Targeted Topical Delivery of Upadacitinib for Enhanced Arthritis Therapy.

ACS applied bio materials·2026
Same author

Designing chemigenetic DNA nanotrap for norepinephrine dynamic imaging in organelles.

Nature chemical biology·2026
Same author

Charge-Driven Bioshield Remodels Diabetic Oral Microenvironment for Accelerated Wound Healing.

Advanced materials (Deerfield Beach, Fla.)·2026

Related Experiment Video

Updated: Aug 31, 2025

OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy
08:34

OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy

Published on: February 5, 2020

6.8K

Molecularly Engineered Protein Glues with Superior Adhesion Performance.

Zili Wang1,2, Xinquan Gu1, Bo Li2

  • 1Department of Urology, China-Japan Union Hospital of Jilin University, Changchun, 130033, China.

Advanced Materials (Deerfield Beach, Fla.)
|August 25, 2022
PubMed
Summary

Researchers engineered novel protein-based bioglues using de novo designed structural proteins. These ultrastrong, biocompatible adhesives offer rapid hemostasis and promote tissue regeneration, outperforming existing surgical glues.

Keywords:
adhesion performanceadhesivesmolecular engineeringstructural proteinswound healing

More Related Videos

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
08:40

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application

Published on: June 8, 2016

14.3K
Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion
06:15

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Published on: August 15, 2016

7.8K

Related Experiment Videos

Last Updated: Aug 31, 2025

OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy
08:34

OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy

Published on: February 5, 2020

6.8K
TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
08:40

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application

Published on: June 8, 2016

14.3K
Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion
06:15

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Published on: August 15, 2016

7.8K

Area of Science:

  • Biomaterials Science
  • Protein Engineering
  • Nanotechnology

Background:

  • Developing effective bioglues for biomedical applications requires balancing strong adhesion with biocompatibility.
  • Rational molecular-level design of protein-based adhesives remains a significant challenge in the field.

Purpose of the Study:

  • To engineer a new generation of protein-based bioglues with enhanced adhesion and biocompatibility through rational molecular design.
  • To investigate the role of arginine in driving supramolecular assembly and liquid-liquid phase separation for adhesive properties.

Main Methods:

  • De novo design of structural proteins incorporating arginine residues.
  • Utilizing supramolecular assembly and liquid-liquid phase separation for glue formation.
  • Evaluating adhesion strength on various surfaces and assessing hemostasis, biocompatibility, and antibacterial efficacy.

Main Results:

  • Achieved ultrastrong adhesion on diverse surfaces, surpassing many existing synthetic and biomimetic glues.
  • Demonstrated rapid visceral hemostasis within 10 seconds.
  • Exhibited outstanding tissue regeneration, good biocompatibility, and potent antibacterial capacity with low minimum inhibitory concentrations.

Conclusions:

  • De novo designed protein glues utilizing arginine-driven phase separation represent a significant advancement in biomaterials.
  • These protein-based adhesives offer a promising platform for surgical applications, including hemostasis and tissue repair.
  • The study provides a general strategy for fabricating mechanically robust, protein-based materials for medical use.