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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

644
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Updated: Aug 31, 2025

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Image-guided intratumoral immunotherapy: Developing a clinically practical technology.

Avik Som1, Jan-Georg Rosenboom2, Alana Chandler2

  • 1Division of Interventional Radiology, Department of Radiology, Massachusetts General Hospital, United States; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, United States.

Advanced Drug Delivery Reviews
|August 25, 2022
PubMed
Summary
This summary is machine-generated.

Intratumoral immunotherapy delivery using polymeric systems can overcome cancer treatment barriers. These systems offer image guidance and controlled release, potentially creating an in situ cancer vaccine for metastatic disease.

Keywords:
CTCancer vaccineHydrogelsImmunotherapyIntratumoral therapyMRIUltrasound

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Area of Science:

  • Oncology
  • Immunology
  • Biomedical Engineering

Background:

  • Immunotherapy has transformed cancer treatment, but many patients do not respond due to immunosuppressive factors.
  • Intratumoral delivery of immune stimulants aims to enhance local and systemic anti-tumor immunity.
  • Current challenges include lack of delivery confirmation, poor drug distribution, and need for repeat injections.

Purpose of the Study:

  • To review the current state of intratumoral immunotherapy delivery.
  • To explore methods for optimizing controlled drug release from delivery systems.
  • To discuss considerations for image-guided delivery, particularly with CT and ultrasound.

Main Methods:

  • Review of existing literature on intratumoral drug delivery systems.
  • Analysis of polymeric drug delivery platforms for controlled release and image guidance.
  • Discussion of clinical considerations for image-guided intratumoral injections.

Main Results:

  • Polymeric drug delivery systems show promise for intratumoral immunoadjuvant delivery.
  • These systems can facilitate image guidance (CT, ultrasound) and controlled drug release.
  • Optimized delivery systems may enable the development of in situ cancer vaccines.

Conclusions:

  • Intratumoral delivery strategies, particularly using polymeric systems, are crucial for improving immunotherapy efficacy.
  • Image-guided, controlled-release systems address key limitations in current approaches.
  • This approach holds potential for treating metastatic cancer via in situ vaccination.