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Updated: Aug 31, 2025

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
Putative Complementary Compounds to Counteract Insulin-Resistance in PCOS Patients
Tabatha Petrillo1, Elisa Semprini1, Veronica Tomatis1
1Gynecological Endocrinology Center, Department of Obstetrics and Gynecology, University of Modena and Reggio Emilia, 41121 Modena, Italy.
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women. This review explores complementary treatments that target insulin resistance, a key feature of PCOS.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Reproductive Health
Background:
- Polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disorder in women of reproductive age.
- Diagnosis relies on the Rotterdam criteria, with insulin resistance and hyperinsulinemia being key etiological factors.
- PCOS presents with diverse clinical manifestations, complicating treatment strategies.
Purpose of the Study:
- To review and analyze complementary and integrative treatments for PCOS.
- To focus on substances that counteract insulin resistance in PCOS patients.
- To provide clinical insights into these alternative therapeutic approaches.
Main Methods:
- Literature review of complementary substances used in PCOS management.
- Analysis of studies focusing on insulin resistance and hyperinsulinemia in PCOS.
- Synthesis of clinical insights from various integrative treatments.
Main Results:
- A variety of integrative treatments have been reported to effectively manage insulin resistance in PCOS.
- Tailored therapeutic strategies are essential, considering BMI, diabetes predisposition, and pregnancy desires.
- Complementary substances offer potential avenues for PCOS management.
Conclusions:
- Insulin resistance is a central aspect of PCOS pathophysiology.
- Integrative treatments show promise in managing PCOS, particularly insulin resistance.
- Personalized treatment plans are crucial for optimizing outcomes in PCOS patients.
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