Related Experiment Video
Updated: Aug 30, 2025
09:54
Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine
Published on: November 4, 2018
8.2K
Cellular Therapies in Pediatric Liver Diseases
Sunitha Vimalesvaran1, Jessica Nulty1, Anil Dhawan1
1Pediatric Liver GI and Nutrition Center and Mowat Labs, Institute of Liver Studies, King's College London and King's College Hospital, London SE5 9RS, UK.
Cells
|August 26, 2022
Summary
Cellular therapies offer promising alternatives to liver transplantation for children with liver disease. Hepatocyte and mesenchymal stromal cell (MSC) transplantation show potential to overcome donor organ shortages and reduce lifelong medication needs.
Area of Science:
- Hepatology and Regenerative Medicine
- Pediatric Gastroenterology and Nutrition
Background:
- Liver transplantation is the primary treatment for pediatric end-stage liver disease.
- Limitations include donor organ scarcity, surgical risks, and lifelong immunosuppression.
Purpose of the Study:
- To review global experiences with hepatocyte and mesenchymal stromal cell (MSC) transplantation.
- To explore the future potential of these cellular therapies as alternatives to liver transplantation.
Main Methods:
- Systematic review of existing literature on hepatocyte transplantation.
- Analysis of studies involving mesenchymal stromal cell (MSC) transplantation in liver disease.
- Evaluation of current world experience and future prospects.
Main Results:
- Cellular therapies, including hepatocytes and MSCs, are emerging as viable alternatives.
- These approaches aim to mitigate the challenges associated with traditional liver transplantation.
Conclusions:
- Hepatocyte and MSC transplantation represent a significant advancement in treating pediatric liver conditions.
- Further research and clinical application of these cellular therapies hold promise for improved patient outcomes.
Related Concept Videos
01:24Liver Regeneration
3.4K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.4K
01:21Stem Cell Therapy for Tissue Regeneration
4.2K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.2K
01:22Bone Marrow Sampling and Transplants
482
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
482
01:22iPS Cell Differentiation
2.8K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.8K
02:50Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K