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Risk of anxiety and depression in patients with uveitis: a Meta-analysis
Bei Cui1, Hong-Zhen Jia1, Li-Xiong Gao1
1Senior Department of Ophthalmology, the Third Medical Centre of Chinese People's Liberation Army General Hospital, Beijing 100039, China.
International Journal of Ophthalmology
|August 26, 2022
Summary
Patients with uveitis face a significantly increased risk of anxiety and depression. This meta-analysis highlights the need for increased psychological support for uveitis patients.
Area of Science:
- Ophthalmology
- Psychiatry
- Public Health
Background:
- Uveitis is an inflammatory eye condition.
- Anxiety and depression are common mental health disorders.
Purpose of the Study:
- To quantitatively assess the prevalence and risk of anxiety and depression in patients diagnosed with uveitis.
- To conduct a meta-analysis to consolidate existing evidence on the psychological impact of uveitis.
Main Methods:
- A systematic literature search was performed across PubMed, Embase, and Cochrane Library databases up to January 2021.
- Included 12 observational studies comprising 874 patients with uveitis.
- Analyzed data using random-effects models to calculate incidence rates and standard mean differences (SMD) with 95% confidence intervals (95%CI).
Main Results:
- A significant association was found between uveitis and anxiety (SMD=0.97) and depression (SMD=0.79).
- Overall morbidities for anxiety and depression in uveitis patients were 39% and 17%, respectively.
- Incidence rates varied by uveitis type: anterior (33% anxiety, 15% depression), infectious (46% anxiety, 22% depression), and unspecified (59% anxiety, 35% depression).
Conclusions:
- Patients with uveitis exhibit a heightened risk for developing anxiety and depression.
- Ophthalmologists and psychologists should prioritize monitoring the psychological well-being of uveitis patients.
- Further high-quality research with detailed data is recommended for more precise conclusions on uveitis and mental health outcomes.
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