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Phytochemicals: A potential next generation agent for radioprotection.

Bimal Prasad Jit1, Subhaswaraj Pattnaik2, Rakesh Arya1

  • 1Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India; School of Life Sciences, Sambalpur University, Jyoti Vihar, Burla 768019, India.

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Plant-derived compounds show promise as radioprotective agents, offering antioxidant and anti-inflammatory benefits against radiation-induced damage. Further clinical trials are needed to explore their therapeutic potential for various radiation exposures.

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Area of Science:

  • Medicinal Chemistry
  • Pharmacology
  • Radioprotection

Background:

  • Ionizing radiation (IR) poses significant public health risks due to increasing radiation technologies.
  • IR causes biological damage via free radicals and oxidative stress, with limited efficacy of current treatments.
  • Traditional Indian medicine offers phytochemicals with potential radioprotective properties.

Purpose of the Study:

  • To review and summarize novel plant-derived chemical compounds with radioprotective potential.
  • To explore natural products as alternatives to conventional radioprotective therapies.

Main Methods:

  • Literature search of various search engines for plant-derived compounds.
  • Focus on secondary metabolites from both land and marine plant sources.
  • Review of compounds with antioxidant, anti-inflammatory, and free radical scavenging activities.

Main Results:

  • Plant and marine compounds demonstrate significant antioxidant, anti-inflammatory, and free radical scavenging abilities.
  • These natural compounds can modulate signaling intermediates involved in radiation-induced pathological conditions.
  • Identified compounds show potential for mitigating radiation stress.

Conclusions:

  • Plant-derived radioprotective agents offer a novel molecular tool against damage from space exploration, IR, nuclear war, and radiotherapy.
  • Compounds from land and marine sources show therapeutic potential for radiation injury.
  • Further clinical trials are essential to establish therapeutic efficacy and modality.