Hyperprolactinaemia and nonpuerperal lactation associated with clomipramine

Area of Science:

• Pharmacology
• Endocrinology

Background:

• Clomipramine is a tricyclic antidepressant.
• Hyperprolactinemia is a condition of elevated prolactin levels.

Observation:

• A patient experienced nonpuerperal lactation (lactation unrelated to childbirth) while on therapeutic doses of clomipramine.
• Elevated plasma prolactin levels were observed concurrently.

Findings:

• Clomipramine therapy was directly associated with both nonpuerperal lactation and elevated prolactin.
• Discontinuation of clomipramine led to the resolution of these symptoms within weeks.

Implications:

• This suggests a potential mechanism of action for clomipramine involving prolactin regulation.
• Clinicians should be aware of this potential side effect when prescribing clomipramine.
• Monitoring prolactin levels may be considered in patients experiencing unexplained lactation.