Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clinical experiences with aclacinomycin-A.

H Furue, T Komita, I Nakao

    Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Processing of CD109 by furin and its role in the regulation of TGF-beta signaling.

    Oncogene·2010
    Same author

    Characterization of recombinant prolyl aminopeptidase from Aspergillus oryzae.

    Journal of applied microbiology·2009
    Same author

    Responses to 5-HT in morphologically identified neurons in the rat substantia gelatinosa in vitro.

    Neuroscience·2009
    Same author

    Efficient production and partial characterization of aspartyl aminopeptidase from Aspergillus oryzae.

    Journal of applied microbiology·2008
    Same author

    Salmonella prevalence in seafood imported into Japan.

    Journal of food protection·2008
    Same author

    Salmonella prevalence and total microbial and spore populations in spices imported to Japan.

    Journal of food protection·2006
    Same journal

    Future Challenges of Molecular Imaging in Oncology.

    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
    Same journal

    Clinical Applications of Theranostics.

    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
    Same journal

    Internal Radiation Therapy.

    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
    Same journal

    The Role of Molecular Imaging in Ion Beam Therapy.

    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
    Same journal

    Molecular Imaging in Photon Radiotherapy.

    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
    Same journal

    Advancements in Intraoperative Imaging for Enhanced Surgical Precision.

    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
    See all related articles

    Aclacinomycin, a novel anthracycline, shows potential clinical activity in cancer patients. Further studies are ongoing to evaluate its efficacy and safety in treating various malignancies.

    Area of Science:

    • Oncology
    • Pharmacology

    Background:

    • Aclacinomycin is a novel anthracycline analog.
    • It is structurally related to adriamycin and daunomycin.
    • The drug contains three distinct sugar moieties.

    Purpose of the Study:

    • To evaluate the safety and preliminary efficacy of aclacinomycin.
    • To determine the maximum tolerated dose and toxicity profile.
    • To explore clinical activity in cancer patients.

    Main Methods:

    • A phase 1 clinical trial was conducted.
    • Twenty-two patients were enrolled.
    • Aclacinomycin was administered intravenously at 20 mg every other day, up to a total dose of 300 mg.

    Main Results:

    Related Experiment Videos

  • Observed toxicities included myelosuppression, nausea, vomiting, and transient liver function abnormalities.
  • Evidence of clinical activity was noted in several patients.
  • This included cases of breast cancer and gastric cancer.

    • Conclusions:

    • Aclacinomycin demonstrated some clinical activity but no complete or partial remissions were achieved.
    • Further investigation is warranted to fully assess its therapeutic potential.
    • Ongoing studies aim to optimize its use in cancer treatment.