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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Imaging Studies for Cardiovascular System V: CT01:28

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Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
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Imaging Studies VII: Vascular Imaging01:19

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DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
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Imaging Studies for Cardiovascular System III: X-Ray01:20

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The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
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Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
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Transthoracic Echocardiography (TTE)
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Targeted Imaging in Atherosclerosis.

Jingjing Li1, Kaixian Wang1, Wei Pan1

  • 1College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, People's Republic of China.

Analytical Chemistry
|August 30, 2022
PubMed
Summary
This summary is machine-generated.

Targeted imaging offers precise diagnosis of atherosclerosis, a cardiovascular disease. Advanced imaging probes identify plaque biomarkers and activated cells for better understanding and treatment.

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Area of Science:

  • Cardiovascular Imaging
  • Molecular Imaging
  • Diagnostic Strategies

Background:

  • Atherosclerosis is a chronic inflammatory disease leading to plaque rupture, stroke, and myocardial infarction.
  • Current diagnostic methods for atherosclerosis are evolving with advanced imaging techniques.
  • Targeted imaging aims to differentiate pathological tissues from normal tissues in atherosclerosis.

Purpose of the Study:

  • To comprehensively review targeted imaging strategies for atherosclerosis diagnosis.
  • To discuss current challenges and future directions in atherosclerosis imaging.
  • To enhance understanding of atherosclerosis progression through precise identification.

Main Methods:

  • Utilizing versatile imaging techniques for atherosclerosis diagnosis.
  • Designing imaging probes that target plaque biomarkers.
  • Developing probes targeting activated cells in atherosclerotic lesions.

Main Results:

  • Targeted imaging accurately distinguishes pathological from normal tissues.
  • Imaging probes reveal biological information on atherosclerosis occurrence and development.
  • Novel strategies focus on specific ligands accumulated in lesion regions.

Conclusions:

  • Targeted imaging is crucial for precise identification and diagnosis of atherosclerosis.
  • Further development of imaging probes and strategies is needed.
  • Improved understanding of atherosclerosis pathophysiology can guide novel therapeutic approaches.