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Updated: Aug 30, 2025
Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
Published on: November 17, 2017
Targeted Imaging in Atherosclerosis
Jingjing Li1, Kaixian Wang1, Wei Pan1
1College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, People's Republic of China.
Insights
Targeted imaging offers precise diagnosis of atherosclerosis, a cardiovascular disease. Advanced imaging probes identify plaque biomarkers and activated cells for better understanding and treatment.
Area of Science:
- Cardiovascular Imaging
- Molecular Imaging
- Diagnostic Strategies
Background:
- Atherosclerosis is a chronic inflammatory disease leading to plaque rupture, stroke, and myocardial infarction.
- Current diagnostic methods for atherosclerosis are evolving with advanced imaging techniques.
- Targeted imaging aims to differentiate pathological tissues from normal tissues in atherosclerosis.
Purpose of the Study:
- To comprehensively review targeted imaging strategies for atherosclerosis diagnosis.
- To discuss current challenges and future directions in atherosclerosis imaging.
- To enhance understanding of atherosclerosis progression through precise identification.
Main Methods:
- Utilizing versatile imaging techniques for atherosclerosis diagnosis.
- Designing imaging probes that target plaque biomarkers.
- Developing probes targeting activated cells in atherosclerotic lesions.
Main Results:
- Targeted imaging accurately distinguishes pathological from normal tissues.
- Imaging probes reveal biological information on atherosclerosis occurrence and development.
- Novel strategies focus on specific ligands accumulated in lesion regions.
Conclusions:
- Targeted imaging is crucial for precise identification and diagnosis of atherosclerosis.
- Further development of imaging probes and strategies is needed.
- Improved understanding of atherosclerosis pathophysiology can guide novel therapeutic approaches.
Abstract:
Atherosclerosis is a chronic inflammatory disease involved in plaque rupture, stroke, thrombosis, and heart attack (myocardial infarction), which is a leading cause of sudden cardiovascular events. In the past decades, various imaging strategies have been designed and employed for the diagnosis of atherosclerosis. Targeted imaging can accurately distinguish pathological tissues from normal tissues and reliably reveal biological information in the occurrence and development of atherosclerosis. By taking advantage of versatile imaging techniques, rationally designed imaging probes targeting biomarkers overexpressed in plaque microenvironments and targeting activated cells by modifying specific ligands accumulated in lesion regions have attracted increasing attention. This Perspective elucidates comprehensively the targeted imaging strategies, current challenges, and future development directions for precise identification and diagnosis of atherosclerosis, which is beneficial to better understand the physiological and pathological progression and exploit novel imaging strategies.
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