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Related Experiment Video

Updated: Aug 30, 2025

Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus

Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus

Published on: September 9, 2020

Hippocampal astrocytes encode reward location.

Adi Doron¹, Alon Rubin², Aviya Benmelech-Chovav¹

¹Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem, Jerusalem, Israel.

|August 31, 2022

Summary

This summary is machine-generated.

Astrocytes in the hippocampus show reward-location-specific activity in familiar environments. This experience-dependent spatial encoding by astrocytes suggests a role in cognitive functions like navigation and reward expectation.

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Last Updated: Aug 30, 2025

Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus

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Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

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Published on: October 21, 2021

Area of Science:

Neuroscience
Cellular Biology

Background:

Astrocytic calcium signaling is crucial for sensory encoding and behavior modulation.
Longitudinal studies of hippocampal astrocyte activity in awake, behaving mice are limited.

Purpose of the Study:

To investigate real-time astrocytic calcium activity in the hippocampus during spatial navigation and reward seeking.
To determine if astrocyte activity encodes spatial information and is dependent on experience.

Main Methods:

Chronic two-photon microscopy was used to image CA1 astrocytes in mice navigating virtual environments.
Mice ran in familiar or novel environments with water rewards, and reward locations were manipulated.
Linear decoders analyzed astrocyte activity for spatial information content.

Main Results:

Astrocytes exhibited persistent ramping activity towards reward locations in familiar environments, but not novel ones.
Shifting reward locations disrupted ramping, which re-emerged with re-familiarization.
Astrocyte activity alone predicted mouse location in familiar environments, but not novel ones.

Conclusions:

Hippocampal astrocytes encode expected reward locations in an experience-dependent manner.
This demonstrates a role for astrocytes in spatial cognition and reward-based learning.
Findings expand the known computational abilities and cognitive functions of astrocytes.