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Updated: Aug 30, 2025

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

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CDK4: a master regulator of the cell cycle and its role in cancer

Stacey J Baker1, Poulikos I Poulikakos1,2, Hanna Y Irie1,3

  • 1Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, Levy Place, NY 10029, USA.

Genes & Cancer
|September 2, 2022
PubMed

Insights

Cyclin-dependent kinase 4 (CDK4) regulates cell cycle progression and development. This review covers CDK4

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • The cell cycle is regulated by cyclins and cyclin-dependent kinases (CDKs).
  • CDK4, with D-type cyclins, drives progression through the G1 phase, preparing cells for DNA synthesis.
  • While compensatory mechanisms exist in Cdk4-null mice, CDK4 is crucial for mammalian development and cancer.

Purpose of the Study:

  • To review the critical role of CDK4 in cell cycle control.
  • To discuss CDK4's involvement in normal development and cancer.
  • To summarize the therapeutic applications of CDK4/6 inhibitors in cancer treatment.

Main Methods:

  • Literature review of scientific articles and clinical studies.
  • Analysis of data on CDK4 function in cell cycle regulation.
  • Examination of the efficacy of CDK4/6 inhibitors in cancer therapy.

Main Results:

  • CDK4 is essential for G1 phase progression and DNA replication.
  • Dysregulation of CDK4 contributes to tumorigenesis.
  • Approved CDK4/6 inhibitors demonstrate significant utility as cancer therapeutics.

Conclusions:

  • CDK4 plays a vital role in cell cycle regulation, development, and cancer.
  • Targeting CDK4/6 with small molecule inhibitors is an effective cancer treatment strategy.
Keywords:
CDK4/6cancercell cyclecheckpoint inhibitortargeted therapy

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