Visible-Light-Induced Imide Synthesis through a Nitrile Ylide Formation/Trapping Cascade
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Updated: Aug 30, 2025

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization
Published on: November 29, 2018
Bao-Gui Cai1, Wei-Zhong Yao1, Lei Li1
1Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, College of Chemistry and Chemical Engineering, Anhui University, Hefei, Anhui 230601, People's Republic of China.
Abstract:
A visible-light-promoted three component reaction of diazo compounds, nitriles, and carboxylic acids is reported. The reaction utilizes acceptor-only diazo compounds as carbene precursors and nitriles as carbene-trapping reagents to form the key nitrile ylides. Under the optimal reaction conditions, a wide range of imide products were obtained in good to excellent yields. The gram-scale synthesis and synthetic application of the imide products to form isoquinoline-1,3(2H,4H)-dione derivatives further proved the value of this method.
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