Sensory processing in 16p11.2 deletion and 16p11.2 duplication
Harriet Smith1, Chloe Lane1,2, Reem Al-Jawahiri1
1Department of Psychology, University of Sheffield, Sheffield, UK.
Summary
Children with 16p11.2 deletions or duplications show significant sensory processing differences. These differences impact daily life, similar to those seen in autistic children.
Area of Science:
- Genetics
- Neurodevelopmental Disorders
- Sensory Processing
Background:
- 16p11.2 deletions and duplications are linked to various neurodevelopmental issues.
- Sensory processing in these cohorts has not been previously detailed.
Purpose of the Study:
- To investigate sensory processing differences in children with 16p11.2 chromosomal variations.
- To assess the impact of these sensory differences on daily functioning.
Main Methods:
- Parents/caregivers of 38 children with 16p11.2 deletion and 31 with 16p11.2 duplication completed sensory questionnaires (SBQ, CSP-2).
- Additional assessments included autistic traits (SRS-2), ADHD traits (Conners 3), anxiety (SCAS-P), and adaptive behavior (VABS-3).
Main Results:
- Both 16p11.2 deletion and duplication groups exhibited clear sensory processing differences.
- Sensory behaviors were more frequent and impactful compared to neurotypical children, resembling those in autistic children.
- Over 70% showed differences in sensory registration; high percentages of duplication group were unusually sensitive or avoidant of stimuli.
Conclusions:
- Sensory processing differences are prevalent and significantly impact children with 16p11.2 deletions and duplications.
- This study provides the first detailed assessment of sensory processing in these populations.
- Understanding these sensory challenges is crucial for clinical management and support.
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