Amalgamation of Nanoparticles within Drug Carriers: A Synergistic Approach or a Futile Attempt?

In recent years, nanotechnology has gained much attention from scientists for the obtainment of significant advances in therapeutic potential. Nano-delivery systems have emerged as an effective way to improve the therapeutic properties of drugs, including solubility, stability, prolongation of half-life, as well as promoting the accumulation of drug at the target site. The nanoparticles have also been incorporated into various conventional drug delivery systems. This review study aims to introduce the amalgamation of nanoparticles into drug carriers. To overcome the limitations of single nanoparticles, such as toxicity, high instability, rapid drug release as well as limited drug loading capacity, a multi-component system is developed. Liposomes, microparticles, nanofibers, dendrimers, etc., are promising drug carriers, having some limitations that can be minimized, and the compilation of nanoparticles synergizes the properties. The amalgamated nanocarriers are used for the diagnostic purpose as well as treatment of various chronic diseases. It also increases the solubility of hydrophobic drugs. However, each system has its advantages and disadvantages based on its physicochemical properties, efficacy, and other parameters. This review details the past and present state of development for the fusion of nanoparticles within drug carriers and future research works are needed for the same.