Dynamic contrast-enhanced fluorescence imaging compared with MR imaging in evaluating bone perfusion during open...

Area of Science:

• Orthopedic Surgery
• Medical Imaging
• Biomedical Engineering

Background:

• Assessing bone blood perfusion is crucial for diagnosing and managing lower extremity bone infections.
• Intraoperative imaging modalities are needed to guide surgical interventions effectively.

Purpose of the Study:

• To investigate the relationship between ICG-based dynamic contrast-enhanced fluorescence imaging (DCE-FI) and intraoperative DCE-magnetic resonance imaging (MRI) for bone perfusion assessment.
• To compare the sensitivity and information provided by these two imaging techniques during orthopedic surgery.

Main Methods:

• Simultaneous ICG-DCE-FI and intraoperative DCE-MRI were performed in three patients with lower extremity bone infections.
• Time-intensity curves were analyzed in corresponding regions of interest for both modalities.

Main Results:

• ICG-DCE-FI demonstrated higher sensitivity to changes in bone blood perfusion.
• DCE-MRI provided superior and complementary information regarding depth-related perfusion.
• The findings suggest a synergistic potential for these imaging techniques.

Conclusions:

• ICG-DCE-FI and DCE-MRI offer distinct yet complementary insights into bone perfusion during orthopedic surgery.
• Further research is exploring the integration of DCE-MRI's depth information to enhance DCE-FI analysis.
• This combined approach holds promise for improved intraoperative assessment of bone infections.