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Optic perineuritis.

George Saitakis1,2, Bart K Chwalisz1,3

  • 1Division of Neuro-Ophthalmology, Department of Ophthalmology, Massachusetts Eye & Ear Infirmary/Harvard Medical School, Boston, Massachusetts, USA.

Current Opinion in Ophthalmology
|September 6, 2022
PubMed
Summary
This summary is machine-generated.

Optic perineuritis (OPN) is an inflammatory condition of the optic nerve sheath. Prompt corticosteroid treatment is crucial for good visual outcomes, as OPN often requires intervention and may indicate underlying systemic disease.

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Area of Science:

  • Ophthalmology
  • Neurology
  • Inflammatory Diseases

Background:

  • Optic perineuritis (OPN) involves inflammation of the optic nerve sheath.
  • OPN can present with gradual visual decline, eye pain, and optic disc edema.
  • It may mimic optic neuritis and can be idiopathic or secondary to systemic diseases.

Purpose of the Study:

  • To review the pathogenesis, etiology, clinical features, management, and prognosis of OPN.
  • To provide a comprehensive overview of optic perineuritis.
  • To highlight diagnostic criteria and treatment strategies for OPN.

Main Methods:

  • Literature review of OPN.
  • Analysis of clinical presentations and diagnostic findings.
  • Evaluation of treatment outcomes and prognostic factors.

Main Results:

  • OPN is characterized by inflammation of the optic nerve sheath.
  • Diagnosis is clinical, confirmed by MRI showing perineural enhancement.
  • Common symptoms include unilateral vision loss, eye pain, and disc edema.

Conclusions:

  • OPN is not self-limited and requires treatment, primarily high-dose corticosteroids.
  • Early steroid therapy leads to rapid improvement and better visual prognosis.
  • Prognosis depends on treatment delay and presence of systemic diseases.