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Related Experiment Video

Updated: Aug 29, 2025

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

A self-contained acoustofluidic platform for biomarker detection.

Xian Chen¹, Chuanchao Zhang¹, Bohua Liu¹

¹State Key Laboratory of Precision Measuring Technology & Instruments, and College of Precision Instrument and Opto-electronics Engineering, Tianjin University, Tianjin 300072, China. xduan@tju.edu.cn.

|September 7, 2022

Summary

This summary is machine-generated.

This study presents a novel acoustofluidic platform using a Lamb wave resonator (LWR) array for integrated microfluidic functions. This versatile system enables point-of-care testing with a handheld device, eliminating the need for moving parts.

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Published on: September 19, 2017

Area of Science:

Acoustofluidics
Microfluidics
Biomedical Engineering

Background:

Microfluidic platforms are crucial for point-of-care (POC) testing.
Current microfluidic systems often face challenges with cost, complexity, and integration of components like micropumps and microvalves.

Purpose of the Study:

To develop a versatile, self-contained acoustofluidic platform for integrated microfluidic functions.
To demonstrate a novel system for POC testing with reduced complexity and no moving parts.

Main Methods:

Utilized a Lamb wave resonator (LWR) array to actuate microfluidic functions including pumping, mixing, switching, and particle trapping.
Integrated acoustic streaming for flow control and developed custom microfluidic structures for variable pumping.
Incorporated a CMOS photo sensor and electronic driver circuit for automated operation.

Main Results:

Achieved on-chip pumping, mixing, fluidic switching, and particle trapping using acoustofluidics.
Demonstrated variable unidirectional pumping by adjusting LWR position and microchannel geometry.
Successfully tested the integrated system for prostate-specific antigen (PSA) sensing, showcasing biocompatibility.

Conclusions:

The developed acoustofluidic platform offers a versatile and integrated solution for POC testing.
The system's design with no moving parts and on-chip integration simplifies complex microfluidic operations.
This technology holds significant potential for advanced POC biomedical applications.