Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pneumonia II: Pathophysiology

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:

Pneumonia III: Complications and Assessment

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...

Pulmonary Tuberculosis IV

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...

Pneumonia I: Introduction

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...

Renal Failure: Dose Adjustments

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Real-World Analysis of Adverse Events in Patients With Triple-Negative Breast Cancer Receiving Therapy per KEYNOTE-522.

JCO oncology practice·2026

Same author

The Pediatric Resident Mental Health Rotation: Implementing the ACGME Requirement.

Rhode Island medical journal (2013)·2026

Same author

Intranasal delivery of dodecyl creatine ester alleviates motor deficits and increases dopamine levels in a 6-OHDA rat model of parkinsonism.

Frontiers in aging neuroscience·2025

Same author

AI-enhanced bioprocess technologies: machine learning implementations from upstream to downstream operations.

World journal of microbiology & biotechnology·2025

Same author

Food Access Matters: Quantifying the Price Differential Across Four Major Food Retailers and a Mobile Market Aiming to Improve Affordable Nutritious Food Access.

Journal of nutrition education and behavior·2025

Same author

Evaluating the impact of a full-service mobile food market on food security, diet quality and food purchases: a cluster randomised trial protocol and design paper.

BMJ open·2025

Search research articles

Related Experiment Video

Updated: Aug 29, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

Lenalidomide induced pneumonitis.

Kelsey Finch¹, Deepankar Sharma¹, Stephanie Wagner¹

¹Lung Institute, Columbus Regional Health, Columbus, IN, USA.

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners

|September 8, 2022

Summary

This summary is machine-generated.

Iatrogenic lung injury from lenalidomide can manifest as a large lung mass, not just diffuse opacities. Promptly discontinuing the drug and initiating steroids led to complete recovery.

Keywords:

Pneumonitis acute fibrinous and organizing pneumonia iatrogenic lung injury immunomodulatory drug lenalidomide

More Related Videos

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Related Experiment Videos

Last Updated: Aug 29, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

Pulmonology
Oncology
Pharmacology

Background:

Iatrogenic lung injury is a rare but serious complication of antineoplastic and immunomodulatory drugs.
Pneumonitis commonly presents with cough, dyspnea, fever, and hypoxemia, often showing diffuse radiographic infiltrates.

Observation:

A case of pneumonitis presented as a 9 cm lung mass following lenalidomide therapy.
Extensive workup excluded infectious and malignant etiologies for the lung mass.

Findings:

Lenalidomide-induced lung injury was suspected as the cause of the lung mass.
Discontinuation of lenalidomide and initiation of corticosteroid therapy resulted in complete clinical and radiographic resolution.

Implications:

This case highlights an atypical presentation of drug-induced pneumonitis.
Emphasizes the importance of comprehensive medication review in diagnosing lung injuries.
Suggests considering lenalidomide as a potential cause of lung masses presenting with pneumonitis symptoms.