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Updated: Aug 29, 2025

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
Published on: February 24, 2023
Self-assemblies with cascade effect to boost antitumor systemic immunotherapy
Ruipeng Li1, Xiaoyu Zhao1, Yunxia Wang1
1School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006, P. R. China. wangyunxia@sxu.edu.cn.
Abstract:
Bio-organic hybrid self-assemblies based on amino acids, conjugated polymers, Fe3+ and enzymes are fabricated with tumor environment-responsive and light-triggered NO release properties. By sequential energy consumption, NO attack and immune activation, FFPG shows boosted antitumor activity toward both primary and distant tumors. The three-level cascade strategy (starvation/NO/immunotherapy) adopted in this work offers a pathway to address the dilemma of low cure rate of malignant tumors.

