Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clonal chromosome abnormalities in two liposarcomas.

F Mertens, B Johansson, N Mandahl

    Cancer Genetics and Cytogenetics
    |September 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Simple guidelines for efficient referral of soft-tissue sarcomas: a population-based evaluation of adherence to guidelines and referral patterns.

    The Journal of bone and joint surgery. American volume·2012
    Same author

    Nonrandom secondary chromosome-aberrations in liposarcomas with t(12, 16).

    International journal of oncology·2011
    Same author

    Nonrandom secondary chromosome-aberrations in synovial sarcomas with t(x-18).

    International journal of oncology·2011
    Same author

    Deep-seated ordinary and atypical lipomas: histopathology, cytogenetics, clinical features, and outcome in 215 tumours of the extremity and trunk wall.

    The Journal of bone and joint surgery. British volume·2008
    Same author

    Chest wall sarcoma: outcome in 22 patients after resection requiring thoracic cage reconstruction.

    Sarcoma·2008
    Same author

    Identification of low-risk tumours in histological high-grade soft tissue sarcomas.

    European journal of cancer (Oxford, England : 1990)·2007
    Same journal

    Letter to the editor regarding the article "Chromosome abnormalities additional to the Philadelphia chromosome at the diagnosis of chronic myelogenous leukemia: pathogenic and prognostic implications".

    Cancer genetics and cytogenetics·2010
    Same journal

    A novel t(10;12)(q21;p13) involving ETV6 in a patient with acute myeloid leukemia.

    Cancer genetics and cytogenetics·2010
    Same journal

    A case of acute myeloid leukemia initially treated as chronic lymphocytic leukemia: what do we know about t(4;12)(q12;p13)?

    Cancer genetics and cytogenetics·2010
    Same journal

    Myelodysplastic syndrome with isochromosome 5p and trisomy 8 after treatment of a multiple myeloma.

    Cancer genetics and cytogenetics·2010
    Same journal

    Chromosomal imbalances in urinary bladder paraganglioma.

    Cancer genetics and cytogenetics·2010
    Same journal

    A pericentric inv(9)(p22q34) of the der(9)t(9;22)(q34;q11.2) is a recurrent secondary anomaly in Ph-positive leukemia.

    Cancer genetics and cytogenetics·2010
    See all related articles

    This study analyzed two liposarcomas using chromosome banding. One mixed type liposarcoma showed a specific t(12;16) translocation, while a pleomorphic liposarcoma had complex chromosomal abnormalities.

    Area of Science:

    • Cytogenetics
    • Oncology
    • Molecular Pathology

    Background:

    • Liposarcomas are malignant tumors of adipocytes.
    • Understanding chromosomal abnormalities is crucial for liposarcoma classification and diagnosis.
    • Chromosome banding (cytogenetic analysis) is a key technique for identifying these abnormalities.

    Observation:

    • Two distinct liposarcoma subtypes were examined using chromosome banding.
    • A mixed type (myxoid and round cell) liposarcoma exhibited a sole t(12;16)(q13;p11) chromosomal rearrangement.
    • A pleomorphic liposarcoma presented with extensive numerical aberrations and multiple marker chromosomes.

    Findings:

    • The t(12;16)(q13;p11) translocation in the mixed liposarcoma aligns with previous findings for myxoid liposarcomas.

    Related Experiment Videos

  • The pleomorphic liposarcoma displayed significant genomic instability, characterized by a high modal chromosome number (94-112) and several clonal structural aberrations including del(1)(p22), del(1)(q23), i(17q), and translocations t(7;?) and t(19;?).

    • Implications:

    • The findings reinforce the diagnostic utility of specific chromosomal translocations in liposarcoma subtyping.
    • The complex karyotype of the pleomorphic liposarcoma highlights its aggressive nature and potential for diverse genetic alterations.
    • Further research into these genetic profiles may lead to improved diagnostic markers and targeted therapies for liposarcoma.