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Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
Published on: March 17, 2022
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[High-output heart failure]
Jean Regina1, Grégoire Racine1, Antoine Moalic1
1Service de médecine interne et des soins intensifs, Hôpital de Nyon, Groupement hospitalier de l'Ouest lémanique, 1260 Nyon.
Revue Medicale Suisse
|September 9, 2022
Summary
High output heart failure (HOHF) is a complex condition characterized by decreased vascular resistance and increased cardiac output. Early diagnosis and etiology-specific treatment are crucial for managing this often under-diagnosed heart condition.
Area of Science:
- Cardiology
- Internal Medicine
Background:
- High output heart failure (HOHF) presents with diverse causes but shares a common mechanism: reduced systemic vascular resistance.
- This can lead to increased metabolic demands, neurohormonal activation, and fluid retention, creating a hyperdynamic state.
Purpose of the Study:
- To define the diagnostic criteria and clinical presentation of high output heart failure.
- To highlight the importance of identifying HOHF, especially in specific patient populations.
Main Methods:
- Review of existing literature and clinical definitions of HOHF.
- Analysis of diagnostic indicators, including elevated cardiac output (cardiac index >4 L/min/m2).
Main Results:
- HOHF is characterized by a hyperdynamic circulatory state and clinical signs of congestion.
- A cardiac index exceeding 4 L/min/m2 is a key diagnostic indicator.
Conclusions:
- HOHF is likely under-diagnosed and warrants active investigation.
- Obese patients and those with heart failure with preserved ejection fraction (HFpEF) are key populations to consider.
- Treatment and prognosis are contingent upon identifying the underlying etiology.
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