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Interstitial fluid pressure as an emerging biomarker in solid tumors
Hooman Salavati1, Charlotte Debbaut2, Pim Pullens3
1Department of Human Structure and Repair, Ghent University, Ghent, Belgium; IBitech- Biommeda, Department of Electronics and Information Systems, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
Biochimica Et Biophysica Acta. Reviews on Cancer
|September 9, 2022
Summary
Elevated interstitial fluid pressure (IFP) in cancer impacts malignancy and treatment response. New imaging techniques offer non-invasive ways to measure IFP, potentially improving cancer treatment strategies.
Area of Science:
- Biomedical Engineering
- Cancer Biology
- Medical Imaging
Background:
- Cancer's physical microenvironment exhibits increased stiffness and interstitial fluid pressure (IFP).
- Elevated IFP is a negative prognostic indicator, influencing cancer's malignant behavior and response to therapy.
Purpose of the Study:
- To provide a comprehensive overview of the origins and role of elevated IFP in cancer.
- To review current invasive and imaging-based methods for IFP measurement.
- To identify obstacles and future directions for clinical implementation of IFP measurement.
Main Methods:
- Review of existing literature on IFP in cancer.
- Discussion of invasive techniques for IFP measurement.
- Exploration of advanced imaging modalities like DCE-MRI and elastography, coupled with numerical simulations.
Main Results:
- IFP is a key component of the tumor microenvironment affecting cancer progression.
- Traditional IFP measurement methods are invasive.
- Advanced imaging and computational approaches show promise for comprehensive biomechanical assessment.
Conclusions:
- Understanding and measuring IFP is crucial for developing strategies to engineer the tumor microenvironment.
- Non-invasive imaging methods combined with modeling offer a path forward for clinical IFP assessment.
- Overcoming current limitations is key to integrating IFP measurement into clinical practice for improved cancer management.
