Biopolymer coating for particle surface engineering and their biomedical applications

Area of Science:

• Materials Science and Engineering
• Biomedical Engineering
• Polymer Chemistry

Background:

• Petroleum-based synthetic polymer coatings face limitations in biomedical applications due to poor biodegradability and biocompatibility.
• A universal surface modification method is needed for diverse particle types, sizes, and structures.
• Biopolymer coatings present a promising alternative for functional particle preparation.

Purpose of the Study:

• To review the preparation of biopolymer coatings on particle surfaces.
• To summarize the applications of biopolymer-coated particles in biomedicine.
• To identify challenges and future directions in biopolymer-based particle surface engineering.

Main Methods:

• Review of literature on surface modification of particles using natural polysaccharides (chitosan, cellulose), polyphenol-based biopolymers (polydopamine, tannic acid), and proteins (amyloid-like aggregates).
• Summarization of preparation techniques for these biopolymer coatings.
• Exemplification of applications in drug delivery, biomineralization, cell/enzyme immobilization, and antimicrobial uses.

Main Results:

• Demonstrated successful application of polysaccharide, polyphenol, and protein coatings on various particles.
• Highlighted diverse biomedical applications including drug loading/release, biomineralization, cell/enzyme protection, and antimicrobial activity.
• Showcased the versatility of biopolymer coatings for functional particle materials.

Conclusions:

• Biopolymer coatings provide a biocompatible and tunable alternative to synthetic polymers for particle surface engineering.
• These coatings enable a wide range of biomedical applications, enhancing particle functionality.
• Further research is needed to address current challenges and explore future potential in this field.