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Oncology during the New Coronavirus Infection Pandemic.

A D Kaprin1, N S Sergeeva1, P V Shegai1

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Summary

The COVID-19 pandemic spurred advancements in Russian oncology research, focusing on new radiopharmaceuticals for targeted cancer therapy and innovative radiation techniques. These developments aim to improve treatment efficacy and overcome resistance in oncological diseases.

Keywords:
COVID-19clinical studiesnuclear medicineoncologysystemic inflammatory response

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiation Oncology
  • Gene Therapy

Background:

  • The COVID-19 pandemic accelerated scientific research in Russia, particularly in oncology.
  • International multicenter studies investigated the impact of COVID-19 on cancer patients and treatment.
  • Focus on developing and applying novel clinical methods in oncology since 2020.

Purpose of the Study:

  • To explore advancements in nuclear medicine for cancer diagnostics and therapy.
  • To introduce new radiation therapy methods, including fast neutron therapy.
  • To investigate novel approaches like gene therapy and oncolytic viruses for cancer treatment.

Main Methods:

  • Development of new domestic radiopharmaceuticals (RPs) for diagnostics and therapy.
  • Intra-arterial radioembolization using RPs with 90Y and 188Re for primary and metastatic tumors.
  • Implementation of remote radiation therapy with fast neutrons.
  • Utilizing platforms for complex pharmacogenomic analysis with machine learning for precise therapy selection.

Main Results:

  • Active development of new radiopharmaceuticals (RPs) for targeted cancer treatment.
  • Introduction of advanced radiation therapy techniques to overcome treatment resistance.
  • Application of pharmacogenomic platforms for personalized cancer therapy selection.
  • Progress in gene therapy and oncolytic virus research for oncological diseases.

Conclusions:

  • Significant progress in nuclear medicine and radiation oncology in Russia driven by the pandemic.
  • New therapeutic strategies, including targeted radiopharmaceuticals and advanced radiation techniques, are being integrated into clinical practice.
  • Multidisciplinary technologies and pharmacogenomics are enhancing precision oncology and treatment outcomes.