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Updated: Aug 28, 2025
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Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
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IS HOMEOSTASIS MODEL ASSESSMENT FOR INSULIN RESISTANCE >2.5 A DISTINGUISHED CRITERIA FOR METABOLIC
Bárbara Ferreira de Mello Barreto1, Giovana Rita Punaro2, Maria Cristina Elias1
1Universidade Federal de São Paulo, Departamento de Medicina-Gastroenterologia, São Paulo, SP, Brasil.
Arquivos De Gastroenterologia
|September 14, 2022
Summary
Homeostasis model assessment-insulin resistance (HOMA-IR) >2.5 identifies patients with metabolic dysfunction-associated fatty liver disease (MAFLD) who have distinct clinical and metabolic characteristics. This marker indicates a greater potential for disease progression in non-alcoholic fatty liver disease (NAFLD).
Area of Science:
- Hepatology
- Metabolic Syndrome
- Endocrinology
Background:
- Insulin resistance (IR) is a key factor in non-alcoholic fatty liver disease (NAFLD) pathogenesis.
- Metabolic dysfunction-associated fatty liver disease (MAFLD) is a recently characterized condition.
- Homeostasis model assessment-insulin resistance (HOMA-IR) is a proposed diagnostic criterion for MAFLD.
Purpose of the Study:
- To evaluate the association of HOMA-IR >2.5 with clinical, metabolic, biochemical, and histological data.
- To analyze these associations in non-diabetic patients diagnosed with NAFLD via liver biopsy.
Main Methods:
- Retrospective, cross-sectional study of 174 non-diabetic NAFLD patients.
- Classification of body mass index (BMI) and metabolic syndrome (MS) using established criteria.
- Automated methods for biochemical tests and immunofluorometric assay for insulinemia.
Main Results:
- Patients with HOMA-IR >2.5 showed a higher prevalence of MS, elevated liver enzymes, and serum ferritin.
- These patients also had a higher prevalence of non-alcoholic steatohepatitis (NASH) and advanced liver fibrosis.
- Multivariate analysis identified MS, hyperferritinemia, and NASH as independent factors associated with altered HOMA-IR.
Conclusions:
- HOMA-IR >2.5 identifies NAFLD patients with specific clinical and metabolic profiles.
- This marker is associated with a higher potential for disease progression.
- HOMA-IR >2.5 is validated as a parameter for identifying patients with MAFLD.
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