Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Slc16a5 (MCT6) knockout induces sex-dependent changes in auditory function, hair cell viability and cochlear transcriptomic programs in the mouse.

Hearing research·2026

Same author

Polygenic risk score analysis of noise-induced hearing loss: An integrated cross-sectional and longitudinal study.

Hearing research·2026

Same author

Advances in Pharmacological Approaches to Tinnitus and Hyperacusis: Insights into Mechanisms, Biomarkers, and Clinical Heterogeneity from an International Scientific Meeting.

Brain sciences·2026

Same author

Hyperacusis-inducing drug candidates.

Hearing research·2026

Same author

Differences of Gradient Connectivity and Ventricle Volumes in Long-Term Sensorineural Hearing Loss Related Cognitive Impairment Correlate With Transcriptional Signatures.

Human brain mapping·2026

Same author

Individual-Level Brain Network Predictors and Distinct Reorganization Mechanism in Sound Therapies for Tinnitus.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026

Same journal

Multivariate prediction of conductive dysfunction in well and NICU newborns using wideband acoustic immittance with acoustic reflex tests.

Hearing research·2026

Same journal

TGF-β signaling regulates flat epithelium formation in severely injured adult mouse utricle through epithelial-mesenchymal transition.

Hearing research·2026

Same journal

Membrane scaffolding in auditory hair cells - a molecular tightrope walk enables lateral wall stiffness and flexibility.

Hearing research·2026

Same journal

Speech-in-noise recognition during hearing protector use: Human performance and acoustic prediction.

Hearing research·2026

Same journal

Estimation of hair cell loss from audiograms.

Hearing research·2026

Same journal

Cochlear size variation in a large-scale international multicentre cohort.

Hearing research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Aug 28, 2025

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

Galectin-3 protects auditory function in female mice.

Celia Zhang¹, Henry J Adler¹, Senthilvelan Manohar¹

¹Center for Hearing and Deafness, University at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA.

Hearing Research

|September 14, 2022

Summary

This summary is machine-generated.

Galectin-3 (Gal-3) deficiency worsens age-related hearing loss, particularly in female mice. This study identifies Gal-3 as crucial for maintaining female cochlear integrity and auditory function.

Keywords:

Age-related hearing loss Cochlea Galectin-3 Mice Sex differences

More Related Videos

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Published on: February 10, 2023

Author Spotlight: Advancements in Cultivating Mouse Hair Cells for Auditory Research

Author Spotlight: Advancements in Cultivating Mouse Hair Cells for Auditory Research

Published on: September 15, 2023

Related Experiment Videos

Last Updated: Aug 28, 2025

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Published on: February 10, 2023

Author Spotlight: Advancements in Cultivating Mouse Hair Cells for Auditory Research

Author Spotlight: Advancements in Cultivating Mouse Hair Cells for Auditory Research

Published on: September 15, 2023

Area of Science:

Otolaryngology
Genetics
Molecular Biology

Background:

Sex differences in sensorineural hearing loss are known but molecular causes are unclear.
Autosomal genes can influence sex-specific disease susceptibility.
Galectin-3 (Gal-3) is involved in various biological processes.

Purpose of the Study:

To investigate the role of Galectin-3 (Gal-3) in age-related auditory function and cochlear integrity.
To determine if Gal-3 deficiency causes sex-specific effects on hearing.

Main Methods:

Compared auditory brainstem response (ABR) thresholds and distortion-product otoacoustic emission (DPOAE) amplitudes in Gal-3 knockout (KO) and wild-type (WT) mice (male and female) from 1 to 6 months.
Assessed age-related outer hair cell loss in the cochlea.

Main Results:

Gal-3 KO mice showed more rapid age-related hearing threshold increases than WT mice.
Female Gal-3 KO mice exhibited significantly greater hearing deterioration across a broad frequency range compared to males and WT mice.
Female KO mice had greater outer hair cell loss and reduced DPOAE amplitudes.

Conclusions:

Gal-3 deficiency exacerbates age-related cochlear degeneration and hearing loss in female mice.
Gal-3 is identified as a sex-dependent molecule critical for maintaining female cochlear integrity.