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Updated: Aug 28, 2025

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
Published on: November 8, 2012
Relating Cognition to both Brain Structure and Function: A Systematic Review of Methods
Marta Czime Litwińczuk1, Nelson Trujillo-Barreto1, Nils Muhlert1
1Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
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Introduction: Cognitive neuroscience explores the mechanisms of cognition by studying its structural and functional brain correlates. Many studies have combined structural and functional neuroimaging techniques to uncover the complex relationship between them. In this study, we report the first systematic review that assesses how information from structural and functional neuroimaging methods can be integrated to investigate the brain substrates of cognition. Procedure: Web of Science and Scopus databases were searched for studies of healthy young adult populations that collected cognitive data and structural and functional neuroimaging data. Results: Five percent of screened studies met all inclusion criteria. Next, 50% of included studies related cognitive performance to brain structure and function without quantitative analysis of the relationship. Finally, 31% of studies formally integrated structural and functional brain data. Overall, many studies consider either structural or functional neural correlates of cognition, and of those that consider both, they have rarely been integrated. We identified four emergent approaches to the characterization of the relationship between brain structure, function, and cognition; comparative, predictive, fusion, and complementary. Discussion: We discuss the insights provided in each approach about the relationship between brain structure and function and how it impacts cognitive performance. In addition, we discuss how authors can select approaches to suit their research questions. Impact statement The relationship between structural and functional brain networks and their relationship to cognition is a matter of current investigations. This work surveys how researchers have studied the relationship between brain structure and function and its impact on cognitive function in healthy adult populations. We review four emergent approaches of quantitative analysis of this multivariate problem; comparative, predictive, fusion, and complementary. We explain the characteristics of each approach, discuss the insights provided in each approach, and how authors can combine approaches to suit their research questions.
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