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Netarsudil-induced corneal honeycombing in childhood glaucomas

Shikha Gupta1, Karthikeyan Mahalingam1, Monika Arora1

  • 1Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India 110029.

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
|September 16, 2022
PubMed

Insights

Netarsudil treatment in children with uncontrolled glaucoma can cause corneal honeycombing, especially in younger patients with high intraocular pressure (IOP) and prior corneal edema.

Area of Science:

  • Ophthalmology
  • Pharmacology

Background:

  • Netarsudil is a medication used to reduce intraocular pressure (IOP).
  • It is prescribed for corneal decompensation or edema in eyes with normal pressure.

Observation:

  • Corneal epithelial edema and honeycombing were observed in children using netarsudil (0.02%) for over two weeks.
  • This occurred in children with uncontrolled IOP (glaucoma) despite maximal topical medication.

Findings:

  • Nine out of sixteen (56%) pediatric eyes developed corneal honeycombing.
  • Affected children were younger (median 3.1 years), had higher baseline IOP (35.6 mmHg), and often had pre-existing corneal edema.

Implications:

  • Netarsudil may induce corneal complications in pediatric glaucoma patients.
  • Further research is needed to understand the risks and mechanisms in this population.

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