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Pulmonary Embolism and Amniotic Fluid Embolism.
Ashley S Coggins1, Erin Gomez2, Jeanne S Sheffield1
1Division of Maternal-Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Phipps 228, Baltimore, MD 21287-4922, USA.
Obstetrics and Gynecology Clinics of North America
|September 19, 2022
Summary
Pregnancy increases the risk of venous thromboembolism (VTE), a major cause of maternal death. This review covers VTE and amniotic fluid embolism (AFE) management in pregnant patients.
Area of Science:
- Obstetrics and Gynecology
- Cardiovascular Medicine
- Maternal Health
Background:
- Venous thromboembolism (VTE) and amniotic fluid embolism (AFE) are significant causes of maternal mortality globally.
- Pregnant individuals face an elevated risk of developing VTE, including pulmonary embolism.
- AFE is a rare but severe complication with poorly understood mechanisms.
Purpose of the Study:
- To review the causes of VTE during pregnancy.
- To examine current evidence-based practices for VTE evaluation, diagnosis, and management in pregnancy.
- To review the causes, diagnostic challenges, and pathogenesis of AFE.
Main Methods:
- Literature review of VTE and AFE in pregnancy.
- Analysis of contemporary diagnostic and management strategies.
- Synthesis of current knowledge on AFE pathogenesis.
Main Results:
- Pregnancy is a prothrombotic state, increasing VTE risk.
- Evidence-based guidelines exist for VTE diagnosis and management in pregnant patients.
- AFE remains a diagnostic challenge with limited understanding of its pathophysiology.
Conclusions:
- VTE is a significant, manageable risk in pregnancy.
- Further research is needed to elucidate AFE pathogenesis and improve outcomes.
- Comprehensive understanding and management protocols are crucial for reducing maternal mortality from embolic events.
Keywords:
Amniotic fluid embolismAnticoagulationDeep vein thrombosisDiagnostic imagingDisseminated intravascular coagulopathyPregnancyPulmonary embolismVenous thromboembolismMore Related Videos
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