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Related Experiment Videos

Anticardiolipin and complement activation: relation to clinical symptoms.

R Norberg, O Nived, G Sturfelt

    The Journal of Rheumatology. Supplement
    |June 1, 1987
    PubMed
    Summary

    High levels of anticardiolipin antibodies are common in systemic lupus erythematosus (SLE) and linked to clotting issues and pregnancy loss. Treatment may improve outcomes by normalizing clotting times.

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    Area of Science:

    • Immunology
    • Rheumatology
    • Obstetrics

    Background:

    • Anticardiolipin antibodies are rarely found in healthy individuals but are prevalent in systemic lupus erythematosus (SLE).
    • Elevated anticardiolipin antibody levels correlate with thromboembolic events, thrombocytopenia, and recurrent pregnancy loss.

    Purpose of the Study:

    • To investigate the prevalence and clinical significance of anticardiolipin antibodies in SLE patients.
    • To assess the impact of disease activity and therapy on anticardiolipin antibody levels and related clinical manifestations.

    Main Methods:

    • Enzyme-linked immunosorbent assay (ELISA) was used to detect anticardiolipin antibodies.
    • Absorption studies with phospholipids were performed to confirm antibody specificity.
    • Complement activation via the classical pathway was assessed in patients with high antibody levels.

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    Main Results:

    • High anticardiolipin antibody levels were observed in SLE patients and women with unexplained recurrent abortions.
    • Antibody levels remained stable despite disease activity and therapy in most cases.
    • Treatment with prednisolone and salicylic acid normalized prolonged activated partial thromboplastin time, aiding successful pregnancies.

    Conclusions:

    • Anticardiolipin antibodies are a significant marker in SLE, associated with adverse clinical outcomes.
    • Therapeutic interventions may mitigate some associated risks, improving pregnancy success.
    • The role of anticardiolipin antibodies in complement activation warrants further investigation.