Teaching NeuroImage: Primary Familial Brain Calcification in SLC20A2 Genotype
Mary Clare McKenna1, Janice Redmond2, David Bradley2
1From the Neurology Department (M.C.M., J.R., D.B., P.B.), St. James's Hospital, Dublin; and Computational Neuroimaging Group (M.C.M., P.B.), Biomedical Sciences Institute, Trinity College Dublin, Ireland. mary.mc-kenna.1@ucdconnect.ie.
Neurology
|September 20, 2022
Abstract
No abstract available in PubMed .
Related Concept Videos
01:29Alzheimer Disease l: Introduction
21
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
21
01:23Alzheimer Disease ll: Pathophysiology
35
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and...
35