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Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
Published on: September 22, 2023
RHINOSINUSITIS IN PATIENTS IN POST-COVID-19 PERIOD: ETIOLOGY, CLINICAL AND MORPHOLOGICAL CHARACTERISTICS
Mykhailo S Myroshnychenko1, Yuliia M Kalashnyk-Vakulenko1, Nataliia V Kapustnyk2
1KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
Post-COVID-19 rhinosinusitis is often chronic and atrophic, caused by bacterial and fungal infections. Identifying these causes and risk factors improves diagnosis and treatment for patients recovering from COVID-19.
Area of Science:
- Otolaryngology
- Infectious Diseases
- Pathology
Background:
- Rhinosinusitis is a common complication following COVID-19 infection.
- Understanding the specific etiology and characteristics of post-COVID-19 rhinosinusitis is crucial for effective management.
Purpose of the Study:
- To identify the causes, clinical presentation, and morphological features of rhinosinusitis in patients post-COVID-19.
- To determine risk factors associated with the development of this condition.
Main Methods:
- Analysis of 11 cases of rhinosinusitis developing after COVID-19.
- Diagnosis based on medical history, clinical/laboratory exams, and advanced imaging (MRI, CT).
- Surgical intervention (endoscopic sanitation, sinusotomy) followed by microbiological, histological, and morphometric analysis.
Main Results:
- Chronic atrophic rhinosinusitis, exacerbated by bacterial (Staphylococcus aureus, Klebsiella pneumoniae) and fungal (Aspergillus, Candida) associations, was identified.
- Fungal infections showed invasion into nasal and sinus mucosa; rhinosinusitis was predominantly bilateral.
- Symptoms included fever, headache, nasal discharge, facial pain, vision changes, and olfactory dysfunction.
Conclusions:
- The study identified etiological, clinical, and morphological features of post-COVID-19 rhinosinusitis.
- Key risk factors include a history of severe COVID-19 and comorbidities like diabetes and hypertension.
- This knowledge aids clinicians in improving diagnosis and treatment strategies.
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