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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
[Hepatitis A virus epidemiology in 2007]
E Dussaix1, V Mackiewicz2, A-M Roque-Afonso1
1Centre national des virus des hépatites à transmission entérique, AP-HP hôpital Paul-Brousse, Service de microbiologie, 94804 Villejuif, Université Paris-Sud, UMR-S 785, 94804 Villejuif.
Abstract:
Improvements in hygienic and sanitary conditions, especially in developing countries, have lead to a progressive shift in the epidemiologic pattern of hepatitis A. This infection, most commonly transmitted via feco-oral route, is now observed in adult patients reflecting the reduced circulation of the hepatitis A virus in many countries. Paradoxically, the risk of more severe disease forms and outbreaks is increased. Vaccination against hepatitis A appears as an effective way to reduce hepatitis A incidence, HAV could be eradicated if routine vaccination of children is implemented in all countries. However, this vaccination is not presently recommended for areas with high overall and age-specific incidence.
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