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[Enteroviruses receptors and cell entry].

N Lévêque1, J Jacques1, F Renois1

  • 1Laboratoire de virologie médicale et moléculaire, CHU de Reims, Avenir Inserm EA/ IFR53, faculté de médecine, avenue Koenig, 51100 Reims.

Virologie (Montrouge, France)
|September 22, 2022
PubMed
Summary

Human enteroviruses are diverse viruses that infect cells using various entry mechanisms. Understanding these pathways is key to developing new antiviral strategies against these adaptable pathogens.

Keywords:
antiviral strategyco-receptorsendocytosisenterovirusgenetic variabilityreceptors

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Area of Science:

  • Virology
  • Molecular Biology

Context:

  • Human enteroviruses (family Picornaviridae) are prevalent infectious agents.
  • Transmission occurs via fecal-oral or airway routes.
  • These viruses exhibit high genetic diversity and variability.

Purpose:

  • To explore the diverse cellular entry mechanisms of human enteroviruses.
  • To highlight the role of viral genetic diversity in adaptation.
  • To identify potential targets for antiviral strategies.

Summary:

  • Enteroviruses utilize specific cell-surface receptors and co-receptors, binding within capsid depressions.
  • Viral entry involves endocytic pathways, including clathrin-coated pits and caveolae, with emerging roles for ARF and Rho GTPases.
  • Genetic diversity enables enteroviruses to exploit multiple entry routes and adapt to cellular environments and immune pressures.

Impact:

  • Elucidates the complex attachment and entry processes of enteroviruses.
  • Identifies viral entry as a critical target for novel antiviral therapies.
  • Contributes to understanding viral adaptation and pathogenesis.