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Updated: Aug 28, 2025
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Porous Silicon Microparticles for Delivery of siRNA Therapeutics
Published on: January 15, 2015
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Multistage rocket: integrational design of a prodrug-based siRNA delivery system with sequential release for enhanced
Qian Jiang1,2, Xiaobing Chen1, Hong Liang1
1National Engineering Research Center for Biomaterials, Sichuan University Chengdu 610064 P. R. China nie_yu@scu.edu.cn.
Nanoscale Advances
|September 22, 2022
Abstract:
An integrated peptide-camptothecin prodrug (RSC) system was designed as a nano-sized multistage rocket for the efficient complexation and controlled sequential release of siRNA and anticancer drug under tumor-relevant reductive and esterase-enriched conditions, which facilitated the avoidance of negative interactions and maximized the synergistic effect.
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