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Probiotics in the treatment of infantile colic: a meta-analysis of randomized controlled trials

YanPing Liu1, Dejian Ma2, XiYan Wang3

  • 1Department of Pediatric Gastrointestinal Surgery, The People's Hospital of Zhangqiu.

Nutricion Hospitalaria
|September 22, 2022
PubMed

Insights

Probiotics show promise in treating and preventing infant colic, offering a potential solution for caregivers. Further research confirms their therapeutic benefits within four weeks of treatment.

Area of Science:

  • Pediatrics
  • Microbiology
  • Gastroenterology

Background:

  • Infant colic presents a significant challenge for caregivers, with ongoing debate regarding effective interventions.
  • Research into the use of probiotics for infant colic remains inconclusive.

Purpose of the Study:

  • To evaluate the efficacy of probiotics in the prevention and treatment of infant colic.
  • To synthesize evidence from randomized controlled trials on probiotic use for infantile colic.

Main Methods:

  • A systematic review and meta-analysis of nine randomized controlled trials.
  • Searched major databases (PubMed, Web of Science, Cochrane Library, Medline, Google Scholar) for trials published before November 2021.
  • Data extraction and quality assessment performed by two independent investigators.

Main Results:

  • Eight trials involving 587 infants with colic were included.
  • Probiotics demonstrated a significantly higher effective rate (RR = 1.88, 95% CI: 1.61 to 2.19, p < 0.00001) compared to placebo.
  • The probiotic group included 228 infants, and the placebo group included 227 infants.

Conclusions:

  • Probiotics may offer significant therapeutic and preventive effects for infant colic.
  • The benefits of probiotics appear most pronounced within four weeks of administration.
  • Findings suggest probiotics as a viable option for managing infant colic.
Abstract

Keywords:
Cólico infantil. Probiótico. Placebo. Tratamiento. Metaanálisis.

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