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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Updated: Aug 28, 2025

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Decrease in Tear Film Lipid Layer Thickness in Patients with Keratoconus.

Wenyan Zhou1, Haozhe Yu1,2, Yun Feng1,2

  • 1Department of Ophthalmology, Peking University Third Hospital, Beijing 100191, China.

Journal of Clinical Medicine
|September 23, 2022
PubMed
Summary
This summary is machine-generated.

The severity of keratoconus correlates with reduced lipid layer thickness and partial blink rate. These changes may indicate corneal abnormalities and increased risk of progression in keratoconus patients.

Keywords:
dry eyekeratoconuslipid layer thicknessmeibomian glandspartial blinktear film

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Area of Science:

  • Ophthalmology
  • Corneal Disease Research
  • Tear Film Dynamics

Background:

  • Keratoconus (KC) is a progressive corneal disorder causing thinning and protrusion.
  • Meibomian gland dysfunction is linked to KC, affecting the tear film's lipid layer.
  • Understanding the relationship between tear film parameters and KC severity is crucial.

Purpose of the Study:

  • To investigate the correlation between lipid layer thickness (LLT), partial blink rate (PBR), and the degree of keratoconus.
  • To assess how these ocular parameters differ in patients with moderate to severe KC compared to healthy controls.

Main Methods:

  • Retrospective study including 78 participants (54 KC patients, 24 controls).
  • Measured anterior corneal curvature, LLT, and PBR in one eye per participant.
  • Statistical analysis to determine correlations and significant differences between groups.

Main Results:

  • Significant differences in corneal curvature, LLT, and PBR were observed between moderate/severe KC groups and controls.
  • A significant negative correlation was found between anterior corneal curvature and LLT in moderate and severe KC.
  • A significant negative correlation was also found between anterior corneal curvature and PBR in KC patients.

Conclusions:

  • Keratoconus severity is associated with decreased LLT and PBR.
  • These findings suggest potential epithelial abnormalities and reduced tear film protection in advanced KC.
  • This may contribute to corneal thinning and weakening through proteolytic enzyme activity.