Related Experiment Video
Updated: Jul 8, 2026

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection
Published on: February 28, 2019
Staphylococcus aureus Causes the Arrest of Neutrophils in the Bloodstream in a Septicemia Model
Svetlana N Pleskova1,2, Sergey Z Bobyk1,2, Ruslan N Kriukov3
1Laboratory of Scanning Probe Microscopy, Lobachevsky State University of Nizhny Novgorod, Gagarina Ave., 23, 603950 Nizhny Novgorod, Russia.
Abstract:
Staphylococcus aureus induces the expression of VCAM-1, P- and E-selectins on the endothelial cells of the EA.hy926 cell line but, at the same time, causes the significant suppression of the force and work of adhesion between these receptors of endotheliocytes and the receptors of neutrophils in an experimental septicemia model. Adhesion contacts between the receptors of neutrophils and endotheliocytes are statistically significantly suppressed under non-opsonized and opsonized S. aureus treatment, which disrupts the initial stage of transendothelial migration of neutrophils-adhesion. Thus, S. aureus causes the arrest of neutrophils in the bloodstream in an experimental septicemia model.
More Related Videos
Related Concept Videos
Determinants of Bacterial Pathogenicity and Virulence
Staphylococcal Skin Infections
Bacterial Meningitis
Mechanism of Antibiotic Resistance in MRSA
Clinical Significance of Antibiotic Resistance

