Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

391
Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
391

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thermally Activated Vaporization of Fluorocarbon-In-Hydrocarbon Exoskeletal Droplets.

ACS omega·2026
Same author

A model for a lipid-coated microbubble based on transient network theory.

The Journal of the Acoustical Society of America·2026
Same author

Clearance of intracranial debris by ultrasound reduces inflammation and improves outcomes in hemorrhagic stroke models.

Nature biotechnology·2025
Same author

Tuning the Shell Elasticity of Phospholipid-Coated Microbubbles via Palmitic Acid Doping.

Langmuir : the ACS journal of surfaces and colloids·2025
Same author

Acoustically activatable liposomes as a translational nanotechnology for site-targeted drug delivery and noninvasive neuromodulation.

Nature nanotechnology·2025
Same author

Frequency-Selective Microbubble Targeting <i>In Vitro</i>: A Step Toward Multicolor Ultrasound Molecular Imaging.

ACS applied bio materials·2025

Related Experiment Video

Updated: Aug 27, 2025

Imaging and Quantification of the Area of Fast-Moving Microbubbles Using a High-Speed Camera and Image Analysis
05:31

Imaging and Quantification of the Area of Fast-Moving Microbubbles Using a High-Speed Camera and Image Analysis

Published on: September 5, 2020

6.0K

Cavitation Characterization of Size-Isolated Microbubbles in a Vessel Phantom Using Focused Ultrasound.

Payton Martinez1,2, Nick Bottenus1,3, Mark Borden1,3

  • 1Biomedical Engineering Program, University of Colorado, Boulder, CO 80309, USA.

Pharmaceutics
|September 23, 2022
PubMed
Summary

Microbubble size and concentration significantly impact focused ultrasound (FUS) acoustic responses. Optimizing gas volume fraction is key for controlled microbubble cavitation in FUS therapies.

Keywords:
focused ultrasoundinertial cavitationpassive cavitation detectionsize-isolated microbubblesstable cavitation

More Related Videos

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
06:02

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

4.0K
Studying Cavitation Enhanced Therapy
07:36

Studying Cavitation Enhanced Therapy

Published on: April 9, 2021

5.3K

Related Experiment Videos

Last Updated: Aug 27, 2025

Imaging and Quantification of the Area of Fast-Moving Microbubbles Using a High-Speed Camera and Image Analysis
05:31

Imaging and Quantification of the Area of Fast-Moving Microbubbles Using a High-Speed Camera and Image Analysis

Published on: September 5, 2020

6.0K
Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
06:02

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

4.0K
Studying Cavitation Enhanced Therapy
07:36

Studying Cavitation Enhanced Therapy

Published on: April 9, 2021

5.3K

Area of Science:

  • Acoustics
  • Biomedical Engineering
  • Materials Science

Background:

  • Focused ultrasound (FUS) with microbubbles (MBs) enables noninvasive, on-demand pharmaceutical delivery.
  • Passive cavitation detection (PCD) provides real-time feedback on MB activity during FUS.
  • Limited research exists on how microbubble parameters influence acoustic responses.

Purpose of the Study:

  • To investigate the acoustic response of different microbubble size populations and concentrations.
  • To understand the relationship between microbubble characteristics and cavitation detection during FUS.

Main Methods:

  • Prepared four microbubble size distributions (2, 3, 5 µm, and polydisperse).
  • Utilized a 1.515 MHz focused ultrasound transducer with varying mechanical indices (MI).
  • Assessed harmonic (HCD) and broadband cavitation dose (BCD) in a phantom model.

Main Results:

  • Cavitation onset (HCD and BCD) depends on MI, MB size, and concentration.
  • Increasing microbubble concentration, at matched MI, leads to a rise, plateau, and decline in HCD and BCD.
  • Combining MB size and concentration into gas volume fraction normalized the acoustic responses across distributions.

Conclusions:

  • Microbubble gas volume fraction is a critical parameter for predicting acoustic response in FUS.
  • These findings can guide the optimization of microbubble parameters for targeted FUS therapies.
  • Understanding these relationships enhances control and planning for MB + FUS procedures.