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Outcomes of Candida and Non-Candida Aortic Graft Infection

Safwan Omran1, Steffen Gröger1, Bashaer Shafei1

  • 1Department of Vascular Surgery, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 14903Charité--Universitätsmedizin Berlin, Berlin, Germany.

Vascular and Endovascular Surgery
|September 23, 2022
PubMed

Insights

Candida-associated aortic graft infections led to longer hospital stays but similar mortality rates compared to non-Candida infections. This study highlights key differences in outcomes for patients with fungal versus bacterial aortic graft infections.

Area of Science:

  • Cardiovascular Surgery
  • Infectious Diseases
  • Medical Microbiology

Background:

  • Aortic graft infection is a severe complication following aortic reconstructive surgery.
  • Distinguishing between fungal (Candida) and bacterial etiologies is crucial for understanding disease progression and outcomes.

Purpose of the Study:

  • To compare the clinical outcomes of aortic graft infections caused by Candida species versus non-Candida pathogens.
  • To identify specific risk factors and clinical presentations associated with Candida-related aortic graft infections.

Main Methods:

  • Retrospective analysis of 66 patients diagnosed with aortic graft infection between 2015 and 2021.
  • Categorization of patients into Candida (n=21) and non-Candida (n=45) groups.
  • Comparison of demographic data, clinical presentation, treatment, and outcomes, including length of stay and mortality.

Main Results:

  • Graft-enteric fistulas were more prevalent in the Candida group (57% vs. 27%, P=.017).
  • Candida albicans was the most common fungal isolate.
  • Patients with Candida infections experienced significantly longer ICU (10 vs. 9 days, P=.012) and hospital stays (33 vs. 22 days, P=.048).
  • No significant differences in in-hospital or 1-year mortality were observed between the groups.

Conclusions:

  • Both Candida and non-Candida aortic graft infections are associated with high morbidity and mortality.
  • While Candida infections do not appear to increase mortality risk, they are linked to prolonged hospitalizations.
  • Further research into targeted antifungal strategies may be warranted.
Abstract

Keywords:
Candidaaortic repairfungalgraftinfection

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