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Panel Sequencing for Targeted Therapy Selection in Solid Tumors

Nicholas Willard1, Lynette Sholl2, Dara Aisner1

  • 1Department of Pathology, University of Colorado, 12705 East Montview Boulevard BioScience 2, Room 4105, Aurora, CO 80045, USA.

Clinics in Laboratory Medicine
|September 23, 2022
PubMed

Insights

Panel-based genetic testing is now essential for solid tumors due to numerous actionable gene alterations and targeted therapies. This review covers its evolution, current use in lung cancer, and future directions for oncology patients.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Diagnostics

Background:

  • Single-target genetic testing is insufficient for modern oncology patients.
  • The number of actionable gene alterations and targeted therapies is rapidly increasing.
  • Solid tumor genetic testing has undergone significant evolution.

Purpose of the Study:

  • To review the evolution of panel-based genetic testing.
  • To discuss the current utility and special considerations of panel testing.
  • To explore future directions in panel-based testing for solid tumors.

Main Methods:

  • Literature review of panel-based testing.
  • Discussion of historical testing modalities.
  • Case examples, including lung cancer, to illustrate usefulness.

Main Results:

  • Panel-based testing has evolved from single-target assays.
  • Panel testing offers advantages for comprehensive genomic profiling.
  • Lung cancer serves as a key example of panel testing utility.

Conclusions:

  • Panel-based testing is a crucial advancement in solid tumor diagnostics.
  • Understanding the pros and cons of panel implementation is vital.
  • Future directions involve addressing challenges and expanding applications of panel testing.
Keywords:
Next-generation sequencing (NGS)PanelSequencingSolid tumorTargetedTherapy

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