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Updated: Aug 27, 2025
Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
Published on: July 5, 2019
Molecular Detection of Oncogenic Gene Rearrangements
Zehra Ordulu1, Valentina Nardi2
1Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Box 100275, Gainesville, FL 32610, USA; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Abstract:
Oncogenic gene rearrangements have been exponentially significant for clinical management of cancer, from diagnosis to therapy and disease monitoring. Testing algorithms should be created with caution, and sample type, accessibility to testing method, turnaround time, and economic aspects should be taken into consideration. Herein, different molecular technologies for detecting these gene rearrangements are discussed and the benefits and limitations of each method are highlighted.
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