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Updated: Aug 27, 2025

In Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation
Published on: March 27, 2016
[Parvovirus capsid carries a phospholipase A2 enzymatic activity]
1Laboratoire de bactériologievirologie-hygiène, Faculté de médecine Jacques-Lisfranc, CHU de Saint-Étienne.
Abstract:
Nonenveloped viruses enter target cells by endocytosis. Prisoner into intracellular vesicles, they use different mechanisms to allow liberation of their genome and its transport in replication and expression sites. The parvoviruses are small nonenveloped single-stranded DNA viruses that should enter the cell nucleus for replication. One of their capsid proteins carries a phospholipase A2 (PLA2) enzymatic activity that is necessary for infectiosity. The viral PLA2 leads to membrane lysis allowing the liberation of the nucleocapsid from vesicles and its transport to the nucleus. The PLA2 could be involved in immunopathologic phenomenon observed during B19 infection in humans.
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